AVERAGE LEVEL OF FACTOR VIII A IN HEALTHY BLOOD DONORS OF PESHAWAR
Objective: The aim of this study is to determine average level of factor VIII in local healthy blood donors of Peshawar.
Material and Method: It was a descriptive cross sectional study conducted in the blood bank of Hayatabad Medical
Complex Peshawar. In this study total number of one hundred and thirty nine (Male n=121, Female n=18) healthy
volunteer blood donors coming for blood donation were included and those donors who have any history of bleeding/
family bleeding history were excluded. At the time of blood donation 3 ml blood were collected in citrated anticoagulant
tube (Blue Top) from donors and immediately sent to hematology laboratory for determination of factor VIII levels.
All donors Factor VIII levels were measured byStago STA Compact Haemostasis analyzer. All data was documented
and analysis was performed by SPSS-20. Mean + SD was analyzed for age and factor VIII level. Analyzed data was
presented in tables and graphs.
Results: Out of these 139 blood donors 78 (56.1%) were found to have Factor VIII levels between 0.5- 1.0 IU/ml and
61(43.9%) had Factor VIII levels between 1.0- 1.5 IU/ml with mean levels of 1.0 ± 0.498 standard deviation. Factor
VIII level was more in females as compared to male. The factor VIII levels were higher in old age group (>50 years).
Conclusions: Factor VIII levels wereperformed in all the blood donors to select FFPs with high levels of Factor VIII given
to the hemophiliac patients to attain maximum replacement deficient individuals. This will avoid volume overload due
to excess FFP transfusion by giving a product of high yield rather than low factor VIII yield.
Key Words: Factor VIII, Hemophilia, Blood donors, Freshfrozen plasma