COMPARISON OF SALBUTAMOL ALONE WITH SALBUTAMOL PLUS IPRATROPIUM BROMIDE IN THE TREATMENT OF ACUTE ASTHMA IN CHILDREN
Introduction: Asthma is one of the most common chronic diseases in children and worldwide its prevalence has
increased dramatically in the last three decades. Nebulized wet aerosol delivery of salbutamol is still considered the
main therapeutic option in the management of acute wheezing episodes in children in the emergency departments.
Objective: To compare the efficacy of salbutamol alone with salbutamol plus ipratropium bromide in the treatment of
acute asthma in children under 2 years of age
Study Design and Setting: This Randomized Controlled Trial study was conducted at the department of pediatrics,
Lady Reading Hospital, Peshawar, (from1st
November 2013 to30th
Subjects and Methods: This study comprised of 41 participants in each group, between the age of 6 month to 2 years
selected by table of random numbers. Self constructed questionnaire including the variables under study was used.
Results: In this study, 82 patients were divided in two Groups equally. All children were between 6 to 24 months of
age. 23 males and 18 females were included in while in group B there were 24 males and 17 females. The efficacy was
significant in both the groups with p-value=0.024.
Conclusion: The comibination use of salbutamol plus ipratropium bromide Nebulization is effective for the treatment
of children with acute asthma in the emergency department.
KEY WORDS: Asthma, Salbutamol, Ipratropium bromide, Efficacy.