GENDER AND AGE WISE EFFECT OF ORAL AZITHROMYCIN IN THE TREATMENT OF ACNE VULGARIS
Introduction: Acne vulgaris is a common inflammatory disorder of the skin that involves pilosebaceous units. The
pathogenesis of acne is multifactorial and is thought to involve excess sebum production, follicular hyperkeratinization,
bacterial colonization, and inflammation. Acne is most common during adolescence, affecting more than 85% of teenagers.
Many therapeutic options exist for treating acne including topical benzoyl peroxide, topical and oral antibiotics,
topical and oral retinoids and oral contraceptives.
Objective: To determine the gender and age wise effect of oral azithromycin in the treatment of acne vulgaris.
Materials and Methods: This descriptive cross sectional study was conducted in the dermatology department Hayatabad
Medical Complex (HMC) Peshawar from Oct 1, 2015 to Mar 31, 2016.
All patients were divided into four groups (15-18, 19 -22, 23-26 and 27+ years). Those having moderate acne vulgaris
on face only were included in the study. Detailed history was taken and complete physical examination was performed
to rule out associated diseases. All Patients were given Azithromycin 500 mg daily before meal for 5 consecutive days
per month for 3 months. Patients were followed up after taking treatment for three months to see the response of the
drug. Response was graded as excellent, good, moderate, mild and no response.
Results: A total of 193 patients divided in four age groups of male 82(42.2%) and female 112(57.7%). There were
significant changes in responses when compared in age groups with p- 0.000 while age wise it shows better results
in female although it was insignificant.
Conclusion: Azithromycin is a better option for treatment of acne vulgaris in Group- II ages and female patients.
Key words: Azithromycin, Acne vulgaris