ANTIBIOTIC SENSITIVITY OF ESCHERICHIA COLI URINARY TRACT INFECTION IN CHRONIC KIDNEY DISEASE VERSUS NORMAL POPULATION

Objectives: To find is there any difference between antibiotic sensitivity of Escherichia coli urinary tract infection in
chronic kidney disease versus normal population.
Material and Methods: This is a prospective study done at Department of Nephrology Khyber Teaching Hospital
Peshawar, from May 2012 to November 2012. Patient with urinary tract infection caused by Escherichia coli were
included into the study. Patients were divided into two groups, depending on their eGFR. We evaluated the antibiotic
sensitivity profile of E.coli UTI in CKD and non CKD groups.
Results: Hundred patients were included in the study and they were divided into two groups that is CKD and non
CKD group, 50 patients in each group. Male to female ratio was 1:1.7 and 1:4 in CKD and non CKD groups
respectively. Â-lactamase inhibitor antibiotic showed more than 90% sensitivity of E.coli in both groups, without any
significant difference. Nitrofurantoin had least sensitivity.
Conclusion: According to our study CKD itself does not affect the sensitivity of antibiotics against E.coli urinary tract
infection.
Key Words Chronic Kidney Disease, Antibiotic Sensitivity, Urinary Tract Infection.