CAUSATIVE ORGANISMS AND THEIR SENSITIVITY PATTERN IN NEONATAL SEPSIS

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Abstract

ABSTRACT
Introduction: Neonatal sepsis is a serious disease, with high rate of morbidity and mortality in developing countries.
The spectrum of organisms that causes neonatal sepsis changes over time and varies from region to region. Therefore
continued surveillance is mandatory to identify the organisms involved in neonatal sepsis and to select an appropriate
empirical therapy according to sensitivity patterns, to reduce neonatal mortality and morbidity.
Objectives: The objectives of my study were to:
1. Identify the micro-organisms causing neonatal sepsis in a tertiary care hospital.
2. Determine the drug sensitivity pattern of the micro-organisms causing neonatal sepsis.
Study Design: It was a descriptive study.
Duration: The duration of the study was one year from 1st of September 2013 to 31st of August 2014.
Setting: The study was carried out in the Department of Pediatrics, Post Graduate Medical Institute, Hayatabad Medical
Complex, Peshawar, a tertiary health care facility.
Materials And Methods: One hundred and forty patients were collected on non-probability convenient sampling.
Neonates having signs and symptoms suggestive of neonatal sepsis with positive blood, urine or cerebrospinal fluid
cultures were included in the study. Cultures were taken before administration of antibiotics.
Results: Among the 140 cases of culture proven sepsis, 86 (61.4%) presented as early onset sepsis and 54 (38.6%)
as late onset sepsis. Among the bacteriological isolates, gram-negative organisms were more common in neonatal
sepsis (75%). Among the organisms isolated, Eschereichia coli (44.3%) were the commonest organism followed by
Staphylococcus aureus (26.3%), Klebsiella (18.6%) and Pseudomonas (12.1%). Most of the organisms were resistant
to Ampicillin. There was significant degree of resistance to Cefotaxime too. Eschereichia coli were mostly sensitive to
Ciprofloxacin (93.5%), Cefipime (83.9%) and Amikacin (74.2%). Staphylococcus aureus were also mostly sensitive to
Ciprofloxacin (81.8%), Cefipime (75.8%) and Amikacin (66.7%).
Conclusion: Eschereichia coli and Staphylococcus aureus are the most common organisms causing neonatal sepsis
and there is a high degree of resistance to Ampicillin and Cefotaxime.
Key Words: Neonatal sepsis, Septicemia, Eschereichia coli, Antibiotic sensitivity, Resistance. 

 

 

Authors: 
Jahanzeb Khan Afridi
Salman Mastan
Rahida Karim
Ahmad Saud Dar

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