CLOMIPHENE CITRATE A MAJOR RISK FACTOR OF MULTIPLE PREGNANCY IN PATIENTS ADMITTED AT KHYBER TEACHING HOSPITAL, PESHAWAR

ABSTRACT
Objective: To find the role of clomiphene citrate as a major risk factor of multiple pregnancy.
Background: Clomiphene citrate is the main drug used to induce ovulation in our set up. Beside other side effects, 
the risk of multiple birth is significant with its use. This study was designed to asses the role of clomiphene citrate as 
a major etiological agent of multiple pregnancy in our patients. 
Material and Methods: This was a descriptive, cross sectional study which continued from may 2013 to August 2014. 
All patient with multiple pregnancy reporting to Gynae Department of Khyber Teaching Hospital were assessed for 
different risk factors of multiple pregnancy. The diagnosis was made by clinical assessment and ultrasound findings. 
Patients were interviewed for clomiphenc citrate use i.e, dose, and duration especially. 
Results: The patients ages ranged from 20-45 years. Most cases 48 (98%) were twin pregnancy while one patient (2%) 
was found with triplet pregnancy. Clomiptiene citrate was found as etiological agent in most cases 58% (29 patients). 
Most of the patients (88%) used low doses 50 mg daily, while 100 mg dose was needed in some cases (10%) for con-
ception. Higher does i.e 150 mg daily, was needed rarely (1%).
Conclusion: Clomiphene citrate is a major etiological agent of multiple pregnancy. Its used should be monitored 
effectively by our gynecologist to decrease the risk of multiple pregnancy in our patients. 
Key words: Clomiphene citrate, ovulation induction, twin pregnancy.