COAGULATION PROFILE IN PRE AND POST HEMODIALYSIS PATIENTS OF END STAGE RENAL DISEASES

Background: Renal failure is a situation in which kidney fails to function adequately. The two forms of renal failure
are acute and chronic. End stage renal disease is the final stage of chronic renal failure where there is a progressive
irreversible deterioration in renal function which can be substituted by renal replacement therapy, hemodialysis (HD),
peritoneal dialysis or transplantation.
Aims & objective: This study was carried out in order to evaluate the changes in coagulation profile and platelets count
that may occur in renal failure patients undergoing hemodialysis.
Study Design: Cross-Section descriptive Study
Subjects and Methods: This study was carried out at Hematology section, Department of Pathology, Institute of
Kidney Diseases, Hayatabad Peshawar. A total of 100 chronic renal failure patient’s blood samples were evaluated
for Coagulation profile by coagulation analyzer Model Sysmex CA500, along with 100 subjects taken as control. The
coagulation profile i.e. Prothrombin time, Activated Partial Thromboplastin time and INR were compared in pre and post
hemodialysis patients. The platelet counts of the CRF patients were performed by Sysmex KX-21 Haematology Analyzer.
Results: The mean pre hemodialysis PT was 16.219 sec ± std 3.257sec with PT control of 11.2 sec, APTT was 33.845
± std 0.937 sec with control APTT of 26.2 sec. Similarly, post hemodialysis mean PT was16.696 sec ± std 1.082 sec
with control of 11.2 sec. APTT was 40.612 sec ± std 1.595 sec with control APTT of 26.2 sec. Post hemodialysis INR
was 4.548 ± std 3.010 while pre hemodialysis INR was 3.776 ± 1.635. These results clearly indicate that both PT and
APTT are prolonged post hemodialysis and the platelet counts are decreased.
Conclusion: The result showed that in coagulation profile, Prothrombin time, Activated partial Thromboplastin time
measured before and after hemodialysis (HD) in renal failure patients were increased as compared to control groups.
While the platelets count showed on decline side in post hemodialysis patients due to heparin used.
The present investigations may help clinicians to initiate precautions before and after dialysis procedures. Therefore
it is recommended that all patients are screened for coagulation profile and platelet count appropriately before and