COMPARISON OF EFFICACY OF ORAL IVERMECTIN AND TOPICAL PERMETHRIN IN THE TREATMENT OF SCABIES

×

Error message

Deprecated function: The each() function is deprecated. This message will be suppressed on further calls in _menu_load_objects() (line 579 of /home/kjmscomp/public_html/old/includes/menu.inc).

Abstract

ABSTRACT
Background: Scabies is a common communicable disease. Various topical therapies are available for treatment of
scabies. There is only one systemic scabicide. This oral drug is easy to administer and has limited side effects.
Objective: To compare the efficacy of oral ivermectin and topical permethrin in treatment of scabies.
Patients and methods: In this quasi experimental study, a total of 194 patients of scabies were enrolled and randomly
divided in 2 groups of 97 each. Oral ivermectin as 200ug /kg and topical 5% permethrin whole body application for
minimum 12 hrs were used in group A and B respectively. In both groups history, examination and microscopy were
carried out at day 0,7, and day 14. Response to treatment was judged as: decrease in severity of pruritus, non appearance
of new lesions and absence of burrows. Each parameter was scored and sum total of individual scores was
used to determine the efficacy.
Results: Average age in group A was 30.23+8.23SD while Group B contains 29.32+ 7.89SD with p-value p=0.543.
Male to female ratio 1.58:1. Efficacy in both the groups was observed insignificant with p= 0.344, 0.513 at day 7 and
day 14 respectively.
Conclusion: There is no significant difference regarding efficacy of oral ivermectin and topical permethrin in treatment
of scabies.
Key Words: ivermectin, permethrin, scabies .

Authors: 
Ghafoor Ullah1
Abdur Rahim Khan2
Sahibzada Mehmood Noor
Shad Muhammad Wazir2
Journal Issue: 

PDF