COMPARISON OF THE EFFICACY OF TAMSULOSIN AND NIFEDIPINE IN THE EXPULSION OF LOWER URETER STONE WITH SIZE BETWEEN 5MM TO 9MM

ABSTRACT
Objectives: Ureteric stones management makes a large part of urological practice. In our study we have compared
efficacy of Tamsulosin and Nifedipine in the expulsion of lower ureter stone with size between 5mm to 9mm.
Material and Method: 168 patients with distal ureter stone were allocated in two groups, 84 in each, at Department of
Urology, Institute of Kidney Diseases, Hayatabad Medical Complex, Peshawar from June 2014 to May 2015. Patients in
group A received 0.4mg Tamsulosin daily and group B receiving 30mg daily of long acting formulation of Nifedipine.
Oral analgesics were prescribed to all patients and were followed after 6 weeks to study the stone expulsion.
Results: There were 118 male and 50 female patients with male to female ratio of 2.36:1. Their age ranged from 15 to
68 years with the mean age of 35.4 years, with the mean age in Group A was 31.6 years and that in Group B was 39.1
years. Adverse effects of the drugs in the form of transient hypotension was observed in 6 patients in Group A while
one patient in Group B, but there was no drop outs because of this effect. The mean size of the stone was 6.7mm in
Group A and 7.2mm in Group B. Sixty eight patients (80.9%) in Group A achieved complete stone expulsion while the
rate of stone expulsion in Group B was 59 out of 84 (70.2%) patients with P value of 0.106.
CONCLUSION: There are conflicting data in literature regarding the superiority of Nifedipine and Tamsulosin .Our study
shows that none of them is superior to the other in the expulsion of moderate sized lower ureter stones.
Key Words: Ureter, Urinary Tract Stone