COMPARISON OF SERUM ENDOTHELIN-1 AND SERUM LEPTIN LEVELS IN PRE-ECLAMPTIC AND CONTROL SUBJECTS IN THIRD TRIMESTER OF PREGNANCY

×

Error message

  • Notice: Trying to get property 'uid' of non-object in og_context() (line 232 of /home/kjmscomp/public_html/old/sites/all/modules/og/og_context/og_context.module).
  • Deprecated function: The each() function is deprecated. This message will be suppressed on further calls in _menu_load_objects() (line 579 of /home/kjmscomp/public_html/old/includes/menu.inc).

Abstract

Background: Pre-eclampsia is one of the leading causes of maternal and foetal morbidity and mortality. The pathophysiology
of pre-eclampsia is not fully understood , however, Endothelin-1 (ET-1) and leptin are assumed to play important
role in the severity of pre-eclampsia.
Objectives: To determine the levels of ET-1 and leptin in pre-eclamptic patients and compare them with normotensive
subjects.
Materials and Methods: This study was conducted in Gyneacology Ward of Hayatabad Medical complex (HMC) under
the supervision of Khyber Medical University (KMU), Peshawar, Pakistan, in the time period of January-September 2014.
The study involved 40 pre-eclamptic and 40 normotensive women in their third trimester of pregnancy. Serum samples
were obtained from all the individuals for determination of ET-1 and leptin concentration.
Results: Mean serum ET-1 and mean serum leptin levels in pre-eclamptic and control groups were 213±76.0mg/mL
vs 97.5±0.1mg/mL, P<0.001 and 288.5±153ng/mL vs 158±55.9ng/mL, P<0.05 respectively. The mean systolic blood
pressure (SBP) and mean diastolic blood pressure (DBP) in pre-eclamtic and control groups were 175.4±16.9mmHg
vs 112.6±11.3mmHg, P<0.001, and 118.0±9.8mmHg vs 73.1±6.9mmHg, P<0.001 respectively. The urinary albumin
excretion was greater in pre-eclamptic women of age group of 34-41years.
Conclusion: As a conclusion, significant high levels of serum ET-1 and leptin in pre-eclamptic women indicates possible
role of ET-1 and leptin in the pathogenesis of pre-eclampsia. Also the elevated level of ET-1 and leptin may help in the
prediction of the disease and may serve as a marker of severity of pre-eclampsia

Authors: 
Anwar Khan Wazir1
Radhia Khan2
Zakkia Khan3
Journal Issue: 

PDF