CORRELATION OF C-REACTIVE PROTEIN WITH SEVERITY OF PRE ECLAMPSIA

ABSTRACT
Objective: The objective of this study is to correlate the level of C - reactive protein with severity of pre eclampsia in
pregnant women and compare it with normotensive pregnant women.
Study design: Cross sectional analytical.
Methodology: This study was conducted in Gynae/obs department of Hayatabad Medical Complex, Peshawar, from
June 2015 to December 2015. In this study 100 pre eclamptic pregnant women were compared with 100 normotensive
pregnant women of the same gestational age and parity for determination of C-Reactive protein (CRP). 5mL of venous
blood was taken under aseptic techniques in sterile tube, followed by centrifugation for the separation of serum. Serum
samples were stored at -4°C for biochemical analysis. CRP levels were measured by ELISA (Enzyme linked immune
adsorbent assay) method.
Results: Mean and standard deviation for CRP, systolic and diastolic blood pressure, were highly significant (p<0.000) in
preeclamptic women as compare to control group. Mean and standard deviation of CRP (10.52±10.24) in preeclamptic
women was highly significant P < 0.000 when compared with control (5.10±6.20).
Conclusion: CRP shows significant correlation with systolic and diastolic blood pressure and is a better predictor of
PE and eclampsia.
Key Words: Preeclampsia, C-Reactive Protein, Eclampsia.