CORRELATION OF MATERNAL CIRCULATING VISFATIN LEVEL WTH CLINICAL AND BIOCHEMICAL PARAMETERS IN PRE-ECLAMAPSIA

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Abstract

Background: Pre-eclampsia is pregnancy specific disorder affecting pregnant women worldwide and is considered
one of the chief complications in pregnancy. Visfatin is an adipokine having major contribution in pathogenesis of PE.
Objectives: The objective of the study was to find correlation of serum visfatin levels with various biochemical and
clinical parameters in PE and normotensive pregnant women.
Materials and Methods: About 160 pregnant women (gestational age > 20 weeks) participated in the present study.
The subjects were further grouped into PE (n=86) and normotensive pregnant women (n=74) as controls. The level
of serum visfatin was determined by ELISA whereas other biochemical parameters were determined by colorimetric
enzymatic methods. The statistical analysis was performed using SPSS version 19. To evaluate the mean differences
and comparison in these groups student’s t test was performed.
Results: The mean level in serum visfatin was statistically significant in PE women as compared to normotensive
women. No significant correlation of visfatin level was found with clinical and biochemical parameters in PE women
when compared with controls.
Conclusion: Statistical significant difference in the mean serum level of visfatin was detected but no significant correlation
was found in clinical and biochemical parameters in PE and controls. Thus the assessment of visfatin is helpful in
the escaping of maternal morbidity/mortality and is also helpful in subsequent dilemma in patients with PE.
Keywords: Visfatin, Pre-eclampsia, Pregnancy, Urinary Albumin

Authors: 
Asmat Shaheen
Zahoor Ahmed1
Musarrat Jabeen3
Rubina Nazli4
Roshan Ali4
Journal Issue: