DEMOGRAPHIC FEATURES OF HYPOTHYROID PATIENTS: IS HIGH DENSITY LIPOPROTEIN CHOLESTEROL (HDL-C), AN INDICATOR OF DISEASE OR TREATMENT EFFECTIVENESS?DEMOGRAPHIC FEATURES OF HYPOTHYROID PATIENTS: IS HIGH DENSITY LIPOPROTEIN CHOLESTEROL (HDL-C), AN INDICATOR O
Objective: To study demographic features of patients with hypothyroidism.
Place and duration of study: Department of medicine KRL Hospital, Islamabad from January 2017 to June 2017.
Methodology: It is a prospective observational study. Forty patients with age ranging from 17-65 years were included.
Fourteen patients were hyperthyroid, thus excluded from study. Out of remaining twenty-six patients (92%) were females
while (8%) were males. Serum triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH), anti-thyroid
peroxidase antibodies, total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low density
lipoprotein cholesterol (LDL-C) were measured. Routine laboratory tests including blood complete picture, liver function
tests, and renal function tests were also performed.
Result: Current study included 40 patients of thyroid disease. Among them 26 were hypothyroid and 14 were hyperthyroid.
Among hypothyroid patients 92.3% (n=24) were females and 7.6% (n=2) were males. Female to male ratio was
(12:1). Mean age was 45.38 ± 9.97 years with age ranging from 26 to 64 years. Average weight was 74.13 ± 13.4 kg
with weight ranging from 42 to 110 kg. Family history was positive in 27% (n=7) of hypothyroid patients. Co-existing
diabetes mellitus was present in 15.38% (n=4). 19.23% (n=5) had previous exposure to interferon and 15.38% (n=4)
had thyroidectomy. 7.69% (n=2) had goitre. Anti-Thyroid Peroxidase (TPO) antibodies were present in 14 patients.
30.76% (n=8) patients had serum cholesterol >200 mg/dl, 34.61% (n=9) had serum triglycerides >170 while Serum
HDL was > 65 mg/dl in 57.69% (n=15) patients. Serum LDL remained normal in all patients as per our laboratory
reference. Lethargy and weight gain was found in 100% and 92.3% respectively.
Conclusion: Female to male ratio was 12:1. High density lipoprotein cholesterol was found to be raised in 57.69%
patients. Anti-thyroid peroxidase antibody was the commonest antibody detected. About one fifth of patients had
interferon induced hypothyroidism.
Key Words: Serum total cholesterol (TC); triglycerides (TG); high density lipoprotein cholesterol (HDL-C); low density
lipoprotein cholesterol (LDL-C); triiodothyronine (T3); thyroxine (T4); thyroid stimulating hormone (TSH).
282 KJMS September-December, 2017, Vol. 10, No. 3