Diagnostic Accuracy of GeneXpert MTB/RIF assay for Tuberculous Meningitis keeping CSF culture as gold standard


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Background: Tuberculous meningitis (TBM) is a very severe type of tuberculosis with high mortality and
severe complications. The early diagnosis and management has a great role in better outcome and prognosis.
Pakistan is ranked 5th in the world in 2010 with a prevalence of 364/100000. Tuberculous Meningitis
with Mycobacterium tuberculosis as a causative agent is a leading cause of morbidity and mortality globally
. This study has been carried out to evaluate GeneXpert MTB/RIF assay diagnostic accuracy on CSF for
Tuberculous meningitis keeping CSF AFB culture as gold standard.
Methods: This cross sectional study has been conducted at a tertiary care hospital Hayatabad Medical

Nauman Idrees
Rabeeka Bakhtiar
Kashif Kamal
Fawad Rahim
Muhammad Asif Khan
Raza Ullah1