EFFECT OF CANNABIS SATIVA EXTRACT ON THE LIVER AND CARDIC ENZYMES OF NORMAL HEALTHY MICE

ABSTRACT
Objective: To evaluate the effect of Cannabis sativa on cardiac and liver enzymes of apparently normal healthy mice.
Material and Methods: This comparative study was carried out at Department of Pharmacy, Institute of Chemical 
Sciences, University of Peshawar and Khyber Medical College, Peshawar in the year 2015 on 100 apparently healthy 
mice meeting the predetermined selection criteria.
Results: Means + SD cardiac enzymes of mice fed on Cannabis extract viz., CPK and LDH were 271.9 + 12.07 IU/L 
& 275.9 + 12.07 IU/L whereas liver enzymes like ALP, ALT & AST were 198.6 + 4.63 IU/L, 49.9 + 0.40 IU/L and AST 
82.40 + 5.83 IU/L and were significantly higher when than normal healthy mice (group A). 
Conclusion: The results of instant study showed that administration of Cannabis sativa extract has acute toxic effect 
on liver and cardiac enzymes in mice.
Key words: Cannabis sativa, mice, cardiac enzymes, liver enzymes, NIH, ICS, KMC, Peshawar.