Effect of L-Type Calcium Channel Blockers,Nifedipine, on the levels of serum Cholecystokinin in domestic rabbits


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Background: Cholecystokinin (CCK) is a small polypeptide. It that functions as a neurotransmitter in the CNS and as
a hormone in the gastrointestinal tract. The release of CCK is from the STC-1 cells of the gut lining mainly by dietary
proteins.CCK plays a major role in the release of bile into the duodenum. Bile emulsifies fats and helps in their
absorption. This shows that CCK may affect lipid homeostasis. A luminal cholecystokinin releasing factor (LCRF) has
been recently discovered. It is known that LCRF is dependent on calcium for its release.Furthermore, LCRF release
is inhibited by L-type calcium channel blocker drugs. Thus Nifedipine, a calcium channel blocker, may affect the
release of CCK. This study was carried to investigate the effect ofNifedipine on serum CCK levels in healthy domestic
rabbits.We intervened with Nifedipine for four weeks and checked for changes in serum CCK and Lipids.

Urooj Yahya
Shahid Ali Shah²
Inayat Shah³,
Shehryar Mohibullah⁴
Afsheen Mehmood⁵
Munir Mengal⁶
Naveed Afzal Khan⁷