ESTIMATION OF CHRONIC RENAL INSUFFICIENCY BY COCKROFT-GAULT FORMULA AND CREATININE CLEARANCE

ABSTRACT
Background/Objectives: To compare the estimation of chronic renal insufficiency by Cockcroft Gault formula and
Creatinine Clearance.
Methodology: The study was conducted in Endocrinology department of Hayatabad Medical Complex, Peshawar.
The laboratory data was collected from 100 inpatients in six months. Data was collected on a structured proforma.
Descriptive analysis was done.
Results: Comparison was made between Cockcroft & Gault (CG) equation and conventional 24 hour creatinine clearance
on 100 cases with mean age was 52 ± 9.5 SD, ranged from 33 to 70 years. The results reveal that mean blood
sugar was 219±80SD accounting 96% type II diabetes. The mean GFR as estimated by the 24 hour creatinine clearance
(CrCl) and CG formula was 75.98 ml/min/1.73m2 and 82.57±28.17 ml/min/1.73m2 respectively resulted the average
mean difference (bias) of 6.6 ml/min/1.73m2 (P< 0.0001).
Conclusion: We concluded that Cockcroft Gault formula over estimates the GRF rate as compared to 24 hour CrCl
however, the creatinine based prediction equation could be a cost effective tool for monitoring the progression of renal
disease.
Keywords: Chronic renal insufficiency, Cockcroft Gault formula, Diabetic nephropathy, Creatinine clearance