FREQUENCY OF APLASTIC ANEMIA AND MEGALOPLASTIC ANEMIA AS CAUSES OF PANCYTOPENIA IN ADULTS

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Abstract

ABSTRACT
Introduction: Pancytopenia is a common problem in clinical and hematological practice. The clinical manifestations
are usually attributable to anemia, leucopenia or thrombocytopenia, which may manifest clinically as pallor, infections
or bleeding problems respectively.
Objective: To determine the frequency of aplastic anemia and megaloblastic anemia in patients with pancytopenia.
Material and Methods: This descriptive cross sectional study was conducted in Medical Department of MTI, LRH from
15th January 2016 to 14th September 2017. We enrolled total of 363 patients. All admitted patients with pancytopenia,
age 18-60 years and both gender were included while patients receiving chemotherapy and radiotherapy, genetic or
constitutional pancytopenia and history of blood transfusion in recent past (within one week) were excluded.
Results: We enrolled a total of 363 patients among them 138(38%) patients were males while 225(62%) patients were
females and mean age was 42 ± 15.84. Forty percent patients had megalobastic anemia while 23% patients had
aplastic anemia.
Conclusion: We conclude that the frequency of megaloblastic anemia was 40% and aplastic anemia was 23% in
patients with pancytopenia.
Key Words: Pancytopenia, Meglaboblastic anemia, Aplastic anemia

Authors: 
Yaseen khan
Syed Athar
Ibrahim Khan,
M. Amjad Taqweem
Muhmmad Bilal Awan

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