FREQUENCY OF HEPATITIS D IN CHRONIC HEPATITIS B PATIENTS VISITING OUT PATIENT DEPARTMENT, HAYATABAD MEDICAL COMPLEX, PESHAWAR
Introduction: A high frequency of hepatitis D infection in chronic hepatitis B patients has been reported in recent
times in studies done in both Punjab and Sindh provinces. However no study had so far been conducted in Khyber
Pukhtunkhwa province regarding this frequency. Hepatitis D serology was used as marker of hepatitis D infection in
chronic hepatitis B patients visiting medical OPD Hayatabad Medical Complex (HMC), Peshawar.
Material & Methods: This cross-sectional study was carried out at medical OPD, Department of Medicine, HMC
Peshawar from 1st Jan, 2014 to 31st Dec, 2014. Consecutive sampling was employed with a total sample size of 191
patients. Patients with CHB of any duration, who were 13 or more years of age and of either sexes were included in
the study. Patients with a history of interferon treatment in the past, patients on immunosuppressive drugs or patients
with concomitant hepatitis C virus (HCV) were excluded. Patients with CHB were identified by two positive HBsAg tests
by ELISA done more than 6 months apart. All patients with CHB were tested for presence of anti-HDV antibodies by
3rd-generation ELISA method.
Results: Overall the prevalence of hepatitis D seropositivity was 47% in our chronic hepatitis B patients. A large proportion
these hepatitis seropositive patients were young males.
Conclusion: A high percentage of patients with CHB in our country are also suffering from concurrent HDV infection.
Majority of these patients are young males. Failure to recognize them can lead to improper treatment of patients suffering
Key Words: Chronic hepatitis B, hepatitis D virus, Age, Prevalence.