FREQUENCY OF NONRESPONDERS AND ITS COMMON GENOTYPES AMONG PATIENTS WITH CHRONIC HEPATITIS C INFECTION UNDERGOING CONVENTIONAL INTERFERON THERAPY
Background: Hepatitis C infects around 170 million people, nearly 3% of world population and considered a worldwide
public health problem. It is the most common cause of chronic liver disease and 20 to 30% patients develop cirrhosis
liver with a risk of hepatocelular carcinoma
Objective: To determine the frequency of non-responders and its common genotypes among patients with chronic
hepatitis ‘C’ virus infection undergoing conventional interferon and Ribavirin therapy.
Methods: This descriptive cross-sectional study was carried out at Gastroenterology Unit of Postgraduate Medical
Institute Government Lady Reading Hospital Peshawar from 1st October 2011 to 30th June 2012 A total sample of 205
patients of either gender was calculated of either gender
Results: Out of 205 patients, 116 (56.6%) were male and 89 (43.4%) were female. 133 (64.9%) patients were responders
and 72 (35.1%) patients were non-responders. Among the Non-responders 4(5.6%) had genotype 1A, 4 (5.6%) had
genotype 2A, 57 (79.2%) had 3A, 1 (1.4%) had genotype 3B and 6 (8.3%) had untypeable genotype.
Conclusion: Conventional interferon Ribavirin therapy is an effective treatment for treatment naive patients of Chronic
Hepatitis C but a significant number of patients don’t respond to this treatment. Among the non-responders the most
common genotype is 3A.
Keywords: Chronic hepatitis C, Interferon, Ribavirin, Genotype