FREQUENCY OF PEPTIC ULCER DISEASE IN P FREQUENCY OF PEPTIC ULCER DISEASE IN P FREQUENCY OF PEPTIC ULCER DISEASE IN P FREQUENCY OF PEPTIC ULCER DISEASE IN P FREQUENCY OF PEPTIC ULCER DISEASE IN PA A A A ATIENTS TIENTS TIENTS TIENTS TIENTS WITH CIRRHOSIS WI

Objective of the Study: To determine the frequency of peptic ulcer disease in patients with liver cirrhosis
Patient and Methods: This study was conducted in the Gastroenterology and Hepatology Department of Hayatabad
medical complex Peshawar. Patients with diagnosed liver cirrhosis were included in the study after applying the
exclusion criteria. Detailed history taking and relevant systemic examination were carried out. Base line investiga-
tions were done for all patients followed by endoscopic examination of the upper GI tract. All this information was
entered into a specially designed proforma. All data was analyzed using SPSS Program 10.0. Descriptive statistics
were calculated for the study variables.
Results: A total of 100 patients with cirrhosis were included in this study out of which 56 (56 %) were male and 44 (44
%) were female patients. 37 patients (37 %) were found to have peptic ulcer disease endoscopicaly. 20 patients (20
%) were having duodenal ulcers, 14 patients (14 %) were having only gastric ulcers while 3 patients (3 %) were
having both gastric and duodenal ulcers. The rest of 63 patients (63 %) were free from peptic ulcer disease.
Conclusion: Peptic ulcer disease is more common in patients with liver cirrhosis than in general population. It is the
second most common cause of upper GI bleed in patients with cirrhosis after varices. The exact cause of this
increased prevalence of peptic ulcer disease among patients with cirrhosis is not known but among many proposed
mechanism impairment in gastroduodenal mucosal defense mechanisms, portal hypertension, poor child class and
H.Pylori are considered to be important. Prophylactic use of medications for peptic ulcer disease in patients with
cirrhosis can not only decrease morbidity among these patients but also decrease hospital admissions and health
budget expenditures.
Key Words: Peptic ulcer disease, cirrhosis, gastric ulcer, duodenal ulcer