FREQUENCY OF SECONDARY MULTI DRUG RESISTANCE TUBERCULOSIS AND ITS COMMON FACTORS IN PATIENTS PRESENTING WITH CATEGORY II FAILURE

ABSTRACT
Background: Tuberculosis is a major cause of morbidity and mortality throughout the world and drug resistance
tuberculosis may threaten efforts to control tuberculosis in the world by reducing the effectiveness of standard short
course chemotherapy.
OBJECTIVE: To determine the frequency of secondary multi drug resistance tuberculosis and common factors leading
to it in patients presenting with category II failure.
Study design: Descriptive (Cross Sectional) Study
Duration of study: 8 months from 1st sep 2011 to 30th april 2012.
Subjects and Methods: 156 CAT- II failure patients of either gende of 10 years old and above sputum was sent for
AFB microscopy. All sputum positive samples for AFB were tested for resistance to Isoniazid and Rifampicin to detect
MDR TB and detailed clinical history was taken to detect common factors leading to MDR TB. Data was analyzed with
SPSS 16.0.
Result: The Mean duration of the Category II treatment at presentation was 26.164weeks ±.49 SD weeks ranging from
20 to 32 weeks. Multi Drug Resistance TB was found in 61(39.1%) patients and among these patients 35(57.4%) were
females and 26(42.6%) were males. Inadequate treatment and irregularity in treatment were 10(16.4%) patients, un
completed first course of treatment in 7(11.5%), Non observed treatment in 6(9.8%), Non availability in 2(3.3%) patients.
Conclusion: Secondary MDR-TB is 39.1% and the two main factors responsible for more than 50% of secondary MDRTB
at the end of 2nd month are Non DOTs treatment and Non smear conversion
Key words: Secondary MDR-TB; Catogary II failure; Category II treatment; DOTs treatment.