PREVALENCE OF HEPATITIS B AND C IN THALASSEMIA MAJOR PATIENTS
Objective: To study the prevalence of Hepatitis B and C Infection in thalassemia major patients
Materials and methods: This reterospective descriptive study was in conducted in thalassaemia center of Women
and Childern Teaching Hospital Bannu KPK Pakistan. The duration of study was two years (1st January,2013 to 31st
A total of 240 thalassemia cases with multiple transfusion were included in this study. Inclusion criteria was all thalassemia
patients who have received multiple transfusions (> 10 transfusions). Exclusion criteria was fresh thalassemia
patients and those with less than 10 transfusions. All these patients were screened for hepatitis B and C by Immunochromatographic
technique (ICT) and in case of positive screening tests these were confirmed by Polymerase Chain
Results: The age range was 01 – 13 years. Male were 142 (59.17%) and female were 98 (40.83%) with male to female
ratio of 1.31:1. Out of these 240 thalassemia patients 22 (9.16%) were positive for hepatitis C antibodies test and 17
(7.08%) were positive for hepatitis B cirus.
Conclusion: This study show high prevalence of HCV and HBV infections in thalassemic patients with increased ratio of
HCV infections as compared to HBV infections.
Key words: Thalassemia major, Hepatitis B and C, Complication of transfusion.