PREVALENCE OF VARIOUS HCV GENOTYPES IN HEPATITIS C PATIENTS ATTENDING HAYATABAD MEDICAL COMPLEX PESHAWAR FOR ANTIVIRAL TREATMENT.

ABSTRACT
Objective: To know the frequency of various HCV genotypes in our local set up.
Subjects and Methods: This study comprising of 92 patients was carried out in OPD of gastroenterology unit HMC
Peshawar from November 2013 to March 2015. Patient age more than 17 years, both genders, treatment experienced
patients with normal hematologic and radiological parameters were included in the study. Patients age more than 70
years, with uncontrolled depressive and other medical illness, pregnant ladies, treatment naïve patients and decompensated
cirrhotics were excluded from the study. Patients were evaluated for treatment with pegylated and ribavirin
by history, clinical examination, routine laboratory investigations, ultrasound abdomen, HCV genotyping and upper GI
endoscopy where considered necessary. Patients who fulfilled the inclusion criteria were included in the study.
Results: Total of 92 patients, 46(50.0%) male and 46(50.0%) female were included in this study. The mean age was
40.57±9.60 with minimum age of 18 years and maximum age of 60 years. Genotype 3a was the most frequent genotype,
present in 54 (58.69%) patients followed by untypeable genotype which was present in 24(28.7%) patients and
genotype 2a was present in 4(4.34%)
Conclusion: Genotype 3a is the most frequently occurring genotype in our local set up patients followed by untypeable
genotype.
Keywords: HCV, Genotype, Interferon, structural protein, non-structural proteins.