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Purpose: To evaluate the efficacy of monthly intravitreal Bevacizumab injections in improving or stabilizing visual outcomes
measured by Snellen’s Visual acuity charts for a variety of ocular diseases.
Material and Methods: This was a prospective private clinic based study in which a total number of 54 eyes of 40
patients with various ocular diseases were included. Intravitreal Bevacizumab injections 1.25mg in 0.05ml was given
monthly for 3 months and follow up for 06 months after the first injection was carried out. The criteria for improvement
was a gain of at least one line on Snellen’s Visual acuity chart, compared to the baseline while stabilization was considered
if the Visual acuity was unchanged relative to the baseline.
Results: A total number of 54 eyes of 40 patients were included in the study. Males were 20 and females were also 20
with an age range of 35-75 years. They were given intravitreal injection of Bevacizumab. In patients with Proliferative
Diabetic retinopathy (PDR) with vitreous hemorrhage 15 eyes (93.75%) showed improvement while stabilization of visual
acuity was noted in 01 eye (6.25%). In Diabetic macular edema (DME) 15 eyes (68.18%) showed improvement, 05 eyes
(22.72%) were stabilized and in 02 eyes (9.09%) visual loss continued. Five eyes (62.5%) with neovascular Age related
macular degeneration (ARMD) showed improvement while visual acuity was stabilized in 03 eyes (37.5%). In Central
retinal venous occlusion (CRVO) 02 eyes (100%) showed improvement. Out of the 04 eyes of Branch retinal venous
occlusion (BRVO) all eyes showed visual improvement (100%). Both eyes (100%) of Myopic choroidal neovascular
membrane (CNV) patients also showed improvement. No systemic side effects of the given treatment were observed.
Conclusion: The treatment with Bevacizumab is beneficial in improving and stabilizing Visual acuity not only in neovascular
ARMD but also in other chorioretinal vascular disorders.

Sofia Iqbal
Zafar ul Islam
Journal Issue: