Original Articles shall report original research relevant to medical and allied sciences. Observational studies (cohort studies, case-control studies, cross-sectional studies, and diagnostic test assessments) and randomized control trials (RCT) are included in this category. A maximum of six authors including the corresponding author will be given credit for original articles.

Original articles shall have a structured abstract (Objective, Methods, Results, Conclusions) of up to 300 words and three to six keywords as per MeSH (Medical Subject Headings).

The main manuscript (excluding abstract, references and tables) shall be not more than 2500 words (3000 words for RCTs) and shall have the following sections: Introduction, Materials and Methods, Results, Discussion & Conclusions.

Introduction section should reflect statement of the problem supported by concise / relevant literature, and rationale.

Materials and Methods section, organized in paragraphs without sub-headings, shall have the following components.

• Ethical review statement
• Study design
• Description of the selection of the observational or experimental subjects
• Study setting
• Study duration
• Sampling method
• Sample size calculations with references
• Follow-up period
• Inclusion and exclusion criteria
• Identification of the methods and apparatus (provide the manufacturer's name and address in parenthesis)
• Identification of all drugs and chemicals

Results section shall present the results in a logical sequence in the text, tables, and illustrations. Tables, figures, and illustrations shall be placed within the text at the point of citation. Emphasize or summarize important observations without repeating all the results mentioned in tables and figures. Both frequencies and percentages should be mentioned, for example, there were 75 (55%) men. Exact p values should be reported. Mean should be with standard deviations. Medians should be with inter-quartile range. Present decimal figures up to 2 decimals only. e.g. 0.02 is correct instead of 0.025. Not more than three tables and one figure/illustration will be allowed. Additional publication fee of Rs. 5,000 / USD 35 will be applicable for each additional figure/illustration. Tables and figures shall be placed within the text at the point of citation.

Discussion section mentions summary of the main results without repeating details from introduction and materials and methods sections. The main results are then reviewed with results of other published literature. Any new findings of the research should be explained in a logical way and its relevance should be highlighted. These can be used for future research or clinical practice. Strengths and limitations of the study should be stated at the end of the discussion in a separate paragraph.

Conclusion section should be reflective of the objective of the study and study design. It should be a summary of the study. Do not use any finding which has not been shown in the results. A new hypothesis may be included if determined by the research.

A declarations section (with the following subheadings: Authors’ contributions, Conflict of interest, Funding, Acknowledgments) shall be placed after Conclusion section and before References.

The manuscript shall be supported by up to 25 references.

It is mandatory to provide institutional / ethical approval letter for the study at the time of submission. The letter shall mention names of all authors, title of the study, name of the approving body, and number and date of approval. This shall also be mentioned in the Materials and Methods section of the manuscript. Randomized control trials should be registered with an international RCT registry prior to initiation of research. The verifiable trial number shall be mentioned on the title page of the manuscript and shall be provided at the time of submission of manuscript.