Patterns of Renal Diseases in Children with Steroids Resistant Nephrotic Syndrome

Abstract

Objective:To find the histological pattern of renal diseases in children with steroid resistant nephrotic syndrome.

Methodology: This was a descriptive study conducted at the division of nephrology, Lady Reading Hospital Peshawar, Pakistan from July 2014 to June 2019. We performed renal biopsies of all children under the age of 15years who presented with steroids resistant nephrotic syndrome (SRNS). 

Results:Total number of patients was 170.  Mean age was 11.76+ 4.2yrs. In 33(19.4%) of children, the histological diagnosis was Minimal Change Disease (MCD), followed by Focal Segmental Glomerulosclerosis (FSGS) in 28(16.4%), Mesangio-proliferative GN in 24(14.1%), and IgM Nephropathy in 21(12.3%). 

Conclusion:MCD was the most common histological pattern of renal disease among children with SRNS followed by FSGS, Mesangio-proliferative GN and IgM Nephropathy.