COMPARISON OF PAROXETINE AND DAPOXETINE IN PREMATURE EJACULATION

Abstract

Objective: To compare the efficacy of Paroxetine and Dapoxetine in premature ejaculation.
Methodology: We enrolled One hundred and twenty-six patients in this study from January 2019
to December 2021 in urology department Medical teaching institute Lady Reading hospital
Peshawar by using convenient sampling technique. Patients were assigned to take either 20mg
OD Paroxetine (n =158) or 30mg OD Dapoxetine(n=159). On follow-up after six weeks, all the
patients were assessed for improvement in intravaginal ejaculation latency timings (IELT). T test
was applied to see any significant difference in both groups assuming P value <0.005 as statistically
significant.
Results: The mean age of the study population was 32.17±8.38 years. The efficacy in term of
increase in the IELT more than one minutes was 82.53% in paroxetine group and 74.60% in
Dapoxetine group with no statistically significant difference in both drugs (p=0.277). The mean IELT
before starting drug was 0.56±0.30 minutes in Paroxetine group and 0.49±0.29 second in
Dapoxetine group. After the treatment, in paroxetine group the timings improved to 5.31±3.27
minutes and to 4.86±3.36 minutes in dapoxetine group. T
Conclusion: Dapoxetine and Paroxetine in dose of 20mg and 30mg have equal efficacy in terms
of
Increasing the intravaginal ejaculation latency time (IELT), so both are equally effective for
treatment of premature ejaculation.
Keywords: Dapoxetine, Paroxetine, Premature ejaculation (PE), sexual disorder