EVALUALTION OF CARICA PAPAYA LEAF EXTRACT ON MEGAKARYOCYTES COUNT: AN ANIMAL MODEL

Abstract

Objective: To determine the effect of Carica Papaya leaf extract on megakaryocytes count in animal model.

Material and Methodology: Laboratory experimental study was designed to achieve the objective and conducted between July and December 2021. Sample size was calculated by using G power with an effect size of 0 .25 and alpha 0.05. The total sample size was 25 which were divided into five groups. Methanolic extract of Carica Papaya leaves was prepared. Thrombocytopenia was induced and extract was given in doses of 250 and 500 mg/Kg. The blood was taken, and slides were prepared. The mean megakaryocytes count was measured per visual field of microscope. Mean values were calculated using Microsoft Excel 2016 and compared within the groups using paired T-test through Statical Package for Social Sciences (SPSS) version 21.

Results: A statistically significant increase in megakaryocytes count was observed with increasing dose of Carica Papaya leaf extract as compared to the control groups (p-valvue < 0.05).

Conclusion: Our study concluded that Carica Papaya extract significantly increases the number of megakaryocytes count in animal model. However, further large-scale studies are required to evaluate its effects on human body.