THE THE MICROBIAL SENSITIVITY AND DRUG RESISTANCE PATTERN OF PATIENTS SUFFERING FROM ENTERIC FEVER

Abstract

Introduction: Enteric fever (typhoid) is one of the most important and quite common bacterial infection in South Asia. About seven million people are affected each year in South Asia with about 75?000 deaths. Not only from Pakistan but also from the rest of the countries of Asia and throughout the world, increasing resistance of the organism is being reported, which we are also seeing in our day to day practice.

Objective:  Objectives of this study were to determine the microbial sensitivity and drug resistance pattern of patients suffering from enteric fever

Material and methods:  After getting approval from the hospital E&RC, all the patients above >14 years who presented with enteric fever, but had not used any antibiotics, were included in the study. Blood, collected from the patients, was sent for culture and sensitivity. All the data was collected on the purposefully predesigned performa.

Results:  A total of 195 patients were included in the study, 66.2% were males and 34.9% were females. On sensitivity reports, 40.5% were resistant to ampicillin, 44.1% to carbapenem, 30.3% to co-trimoxazole, 48.7% to ciprofloxacin, 35.4% to cefixime, 35.9% to amikacin, 46.7% to ceftriaxone, 34.9% to polymyxin B, 49.2% to chloramphenicol and 55.4% to gentamicin.

Conclusion: Antibiotic resistance against commonly used antibiotics is significantly high in our patients with enteric fever.