COMPARISON OF ESTIMATED PROTEIN EXCRETION RATE WITH PROTEIN CREATININE RATIO IN RELATION TO 24 HOUR URINARY PROTEIN IN HEALTHY INDIVIDUALS
DOI:
https://doi.org/10.70520/kjms.v17i2.477Keywords:
Protein-to-Creatinine Ratio, estimated Protein Excretion Rate, Sub-nephrotic proteinuria, Nephrotic proteinuriaAbstract
Background
Protein-to-Creatinine Ratio (PCR) is used as an alternative to 24-hour urinary protein excretion. PCR has only one drawback that it cannot assess the nephrotic range proteinuria accurately. Estimated protein excretion rate can be an alternative to PCR in cases where PCR fails to detect high grade proteinuria.
Methods
It was an analytical cross sectional study. Seventy five healthy subjects from both genders who were potential donors of renal transplant were selected by non-probability consecutive sampling technique. Urine samples for spot PCR were taken after patients were done with their 24-hours urine collection. Estimated Protein Excretion Rate (ePER) was calculated by using PCR and estimated Creatinine Excretion Rate (eCER) equation. Twenty four hour urinary protein, PCR and ePER were expressed as medians and interquartile ranges (IQRs). Spearman correlation was applied to assess the correlation among 24-hour urinary protein loss, PCR and ePER.
Results
Mean age of the subjects was 33.75 ± 13.75 years. On categorization of subjects for proteinuria, according to PCR, out of 75, 70 subjects were sub-nephrotic and 5 were nephrotic while according to 24-hour protein excretion, only 30 subjects were sub-nephrotic, 1 nephrotic and 44 were normal. On spearman correlation, PCR, ePER (males) and ePER (females) showed significant correlation (<.001) with 24 hour urinary protein.
Conclusion
The study could not prove that ePER is superior to PCR in relation to twenty four hour urinary protein. Both ePER and PCR can equally predict the proteinuria in relation to twenty four hour urinary protein loss.