HYPONATREMIA IN LIVER CIRRHOSIS: A RETROSPECTIVE STUDY AT A TERTIARY CARE HOSPITAL
DOI:
https://doi.org/10.70520/kjms.v17i4.626Keywords:
Liver Cirrhosis, Hyponatremia, Liver FailureAbstract
Objective: This study’s main objective was to ascertain the frequency of hyponatremia in patients with liver cirrhosis and to assess its relationship with the severity of liver cirrhosis and the duration of liver cirrhosis.
Materials and Methods: This retrospective study was carried out in Gastroenterology unit at Hayatabad Medical Complex Peshawar after approval from the hospital's ethical committee. A total of 175 patients with liver cirrhosis who fulfilled the inclusion criteria were included. Patients were categorized according to the Child-Pugh score into three classes. Serum sodium level was determined in the hospital laboratory. Patients were labeled to have hyponatremia if their blood sodium level was less than 135 mmol/L. The Statistical Package for the Social Sciences (SPSS) version 25 was used for data analysis.
Results: The participants in our study were from 18 to 60 years. The mean age was 46.68 ± 10.24 years. This study has more male participants than females. 48% of the participants in this study had hyponatremia. The mean serum sodium level was 131.36 ± 6.51 mmol/L. Disease duration and Child-Pugh class are significantly associated with hyponatremia (p <0.001). Age, gender, and BMI had no significant association with hyponatremia.
Conclusion: Hyponatremia is a common electrolyte abnormality in liver cirrhosis. Prolonged duration of liver cirrhosis and patients with advanced liver disease (Child-Pugh class C) are more likely to have hyponatremia.
References
1. Nishikawa H, Osaki Y. Liver cirrhosis: evaluation, nutritional status, and prognosis. Mediators of inflammation. 2015;2015(1):872152.
2. Asrani SK, Devarbhavi H, Eaton J, Kamath PS. Burden of liver diseases in the world. Journal of hepatology. 2019;70(1):151-71.
3. Bernardi M, Ricci CS, Santi L. Hyponatremia in patients with cirrhosis of the liver. Journal of clinical medicine. 2014;4(1):85-101.
4. Jiménez JV, Carrillo-Pérez DL, Rosado-Canto R, García-Juárez I, Torre A, Kershenobich D, et al. Electrolyte and acid–base disturbances in end-stage liver disease: a physiopathological approach. Digestive diseases and sciences. 2017;62:1855-71.
5. Qureshi MAM, Zubair N, Rafiq M. Frequency of Hyponatremia in Patients with Liver Cirrhosis. PJMHS. 2017;11(2):562-5.
6. Mumtaz M, Ahmad W, Khan AH. Frequency of Hyponatremia in patients of Chronic Liver Disease. Age (Years). 2017;46:15.82.
7. Butt AS. Epidemiology of viral hepatitis and liver diseases in Pakistan. Euroasian journal of hepato-gastroenterology. 2015;5(1):43.
8. Barakat AAE-K, Metwaly AA, Nasr FM, El-Ghannam M, El-Talkawy MD. Impact of hyponatremia on frequency of complications in patients with decompensated liver cirrhosis. Electronic physician. 2015;7(6):1349.
9. Ginés P, Berl T, Bernardi M, Bichet DG, Hamon G, Jiménez W, et al. Hyponatremia in cirrhosis: from pathogenesis to treatment. Hepatology. 1998;28(3):851-64.
10. Azam MU, Javed S, Memon MYY, Aftab MA, Shafqat MN, Sadiq HZ, et al. Hyponatremia Prevalence in Decompensated Chronic Liver Disease: Insights from a Tertiary Care Hospital. Cureus. 2024;16(9):e68907.
11. Shaikh S, Mal G, Khalid S, Baloch GH, Akbar Y. Frequency of hyponatraemia and its influence on liver cirrhosis-related complications. JPMA The Journal of the Pakistan Medical Association. 2010;60(2):116-20.
12. Jenq CC, Tsai MH, Tian YC, Chang MY, Lin CY, Lien JM, et al. Serum sodium predicts prognosis in critically ill cirrhotic patients. Journal of clinical gastroenterology. 2010;44(3):220-6.
13. Guevara M, Baccaro ME, Torre A, Gómez-Ansón B, Ríos J, Torres F, et al. Hyponatremia is a risk factor of hepatic encephalopathy in patients with cirrhosis: a prospective study with time-dependent analysis. Official journal of the American College of Gastroenterology| ACG. 2009;104(6):1382-9.
14. Ginès P, Guevara M. Hyponatremia in cirrhosis: pathogenesis, clinical significance, and management. Hepatology. 2008;48(3):1002-10.
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