Hepatoxicity in patients using DOT therapy in Bannu, khyber pakhtunkhwa, Pakistan

Main Article Content

Mohammad Shoaib Khan
Sajid Khan
Amjed Mustafa
Mohammad Zohaib Khan
Ikram Ul Haq


Background: Tuberculosis is an infectious and serious major health problem that leads to approximately three million
deaths every year throughout the developing world. Although, ATT drugs have been used globally to control tuberculosis.
Yet, it is reported as one of the causes of hepatotoxicity.
Objective: Hepatotoxicity in TB patients using DOT therapy in District Bannu, Pakistan.
Methods: This cross-sectional comparative study was conducted in DHQ teaching Hospital Bannu, Khyber Pakhtunkhwa,
Pakistan, in one year period from February, 2015 to Jun 2019.
Result: In this study of total 100 cases, male were 42% and female were 58% with male to female ratio was 0.72. Illiterates
were 79% and educated were 21%. The commonest age group was 44-48 years. 37% patients showed no hepatotoxicity,
57% were with mild LFT alteration while 6 % developed marked hepatotoxity. The values of ALT before and after
using ATT were compared by applying paired t-test and the statistical analysis(p-value) showed significant differences.
Conclusion: This study show high Hepatotoxicity in district Bannu especially very high prevalence in rural areas when
compared to urban areas. Also the ratio is high in females as compared males and the commonest age group involved
were 21 -40 years.


Article Details

Original Article