EFFECT OF VITAMIN E ON CHEMICALLY INDUCED HEPATIC FATTY DEGENERATION AND PORTAL INFLAMMATION IN ALBINO

Abstract

Objectives: To determine the antioxidant effect of vitamin E against carbon tetrachloride (CCl4) induced fatty degeneration and portal inflammation in the liver of albino mice.

Study design: Analytical experimental study. This study was performed on different groups of albino mice to determine the antioxidant effect of vitamin E against carbon tetrachloride (CCl4) induced fatty degeneration and portal inflammation in the liver.

The study duration was 5 months. The animals were randomly distributed into five groups A, B, C, D and E .The group A served as control group, group B was administered only with CCl4 (no vitamin E) and groups C, D and E received test drug (vitamin E) in different doses along with CCl4. At the end of experiment, the livers were dissected for microscopic study, carried out in research laboratory of Khyber Medical College Peshawar.

Results: The results revealed highly significant difference (p value less than 0.05) in degree of fatty changes and portal inflammation in groups treated with CCl4. The animals administered with 50 mg of vitamin E showed reduction in severity of these parameters.

Conclusions: This study reveals that fatty changes and portal inflammation in liver caused by CCl4 can be reduced by vitamin E in dose of 50 mg/kg body weight.