DIAGNOSTIC ACCURACY OF TRIPLE PHASE COMPUTED TOMOGRAPHY IN DETECTING HEPATOCELLULAR CARCINOMA KEEPING HISTOPATHOLOGY AS GOLD STANDARD

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Mahnoor Rehman Khan
Mehreen Samad
Mahrukh Rehman Khan
Humaira Anjum
Kalsoom Nawab
Ghazala Wahid

Abstract

Objective: The aim of this study is to determine the accuracy of triple phase computed tomography in detecting hepatocellular carcinoma keeping histopathalogical evaluation as gold standard.


Materials and Methods: A study was conducted in the in the Radiology Department of Khyber Teaching Hospital, Peshawar from 18-03-2016 to 18-09-2016. Through a Descriptive Cross Sectional Study Design, a total of 365 patients suspected of having HCC were included in the study in a consecutive manner and subjected to triphasic CT followed by histopathology for the confirmation of HCC.


Results: 40.9 + 11.7 years was the mean age of patients. We had 60% males & 40% females. On CT we observed that the HCC was recorded in 60.3% of patients compared to 49.9% on histopathology. On applying the formulae for calculation, sensitivity of CT was found to be 90.1% and specificity 69.3%. The positive predictive value of the CT is 74.5% and negative predictive value is 87.5%.


Conclusion: Triphasic CT has shown high sensitivity and specificity for HCC detection. As such, it is a useful radiological marker for diagnosis of HCC in adults and further studies are recommended to confirm its usefulness.

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