CORRELATION OF SEX DIFFERENCE AND ASYMMETRIC DIMETHYL ARGININE WITH DIABETES MELLITUS AND CORONARY ARTERY DISEASE

Abstract

OBJECTIVE: To determine the impact of sex differences on diabetes and CAD and to find out association of serum ADMA with glycosylated hemoglobin in type 2 diabetic patients with and without coronary artery disease.

METHOD: This cross sectional study was conducted in KTH and HMC from 2010 to 2011 to evaluate ADMA in type 2 diabetic patients with and without coronary artery disease. This comprised of three groups of 70 participants in each. Group A was normal individuals, B consisted of patients suffering from type2 diabetes mellitus, while C comprised of patients having type 2 diabetes mellitus with coronary artery disease.

RESULTS: An elevated ADMA was noted in diabetic subjects with and without coronary artery disease (03.9±1.5umol/L and 02.0±0.6 vs. 0.6±0.2 umol/L). Among group C strong correlation was noted between serum ADMA level and fasting blood glucose (r = 0.366, p = 0.0001), total cholesterol and triglyceride level (r = 0.392, p = 0.010; r = 0.496, p = 0.001) respectively. In group B a  significant strong  positive  linear relationship was seen between ADMA level and FBS ( r = 0.743 , p =0.001 ) , HbA1c   (r=0.682 , p = 0.001 ) , LDL ( r = 0.508 , p = 0.001 ). However, sex differences had no impact on ADMA & thus on diabetes or CAD.

Conclusion: Our study reveals increased serum ADMA levels in both the diseased groups. Furthermore a significant positive correlation was seen between serum ADMA levels with fasting blood glucose, & HbA1c.