CORRELATION OF ADIPONECTIN WITH SERUM INSULIN IN DIABETICS WITH AND WITHOUT CORONARY HEART DISEASE

Abstract

Background: Coronary heart disease is a common complication of diabetes mellitus.
Hyperinsulinemia associated with diabetes contributes to risk of coronary heart disease. Adiponectin
is known to have anti-inflammatory and insulin sensitizing actions and may have a cardioprotective
role.
Objective: To evaluate association of serum adiponectin with insulin in diabetic patients with and
without coronary heart disease in province of Khyber Pakhtunkhwa.
Methods: This was a descriptive/ analytical study and consisted of three groups. Group A contained
100 diabetic patients, group B contained 100 diabetic patients with coronary heart disease and group
C contained 100 normal controls. The study subjects were randomly selected from Hayatabad
Medical Complex, Khyber Teaching Hospital and Lady Reading Hospital, the three tertiary care
hospitals of Khyber Pakhtunkhwa. Levels of adiponectin, insulin, fasting blood glucose, glycated
hemoglobin were estimated. Variables were compared using independent student’s t test and
correlation between adiponectin with variables was established with Pearson’s correlation coefficient.
Results: Adiponectin was significantly decreased and insulin was increased (P= 0.0001) in diabetics
with and without coronary heart disease. Adiponectin and insulin did not differ significantly between
diabetics with and without coronary heart disease. FBG (190.5±92.7, 185.5±80.05 vs. 88.1±21.3) and
HbA1c (8.8±1.1, 8.6±0.5 vs. 7.03±3.4, P< 0.05) were significantly higher in diabetics with and without
coronary heart.
Adiponectin showed significant negative correlation with FBG (r -0.582), HbA1c (r -0.794) and insulin
(r -0.844).
Conclusion: We found reduced adiponectin levels correlating negatively with insulin in diabetic cases
with and without coronary heart disease.