CO-EXISTENCE OF SQUAMOUS CELL CARCINOMA OF MANDIBLE AND NEUROENDOCRINE TUMOR OF INTESTINE

Abstract

Background: The coexistence of two separate primary cancers in a single patient is a rare clinical event, especially when it involves squamous cell carcinoma (SCC) of the mandible and neuroendocrine tumor (NET) of the small intestine. Because of the differences in tumor biology, development, and management techniques, these instances provide major diagnostic and therapeutic problems.

Case presentation: We present the case of a 55-year-old female with moderately differentiated keratinizing SCC of the right mandible that was treated with surgical resection and adjuvant therapy. She had two recurrences over the course of two years. She later developed gastrointestinal symptoms, and imaging revealed hepatic lesions and a small bowel obstruction. Histopathology after intestinal resection revealed a well-differentiated Grade 2 ileal NET with lymphovascular invasion and nodal metastasis.

Conclusion: This case illustrates the unusual combination of oral cavity SCC and small intestine NET, presenting crucial questions about cancer survivors' surveillance and the possibility of additional primary malignancies with unique histopathologies. Awareness of such relationships is critical for timely diagnosis and effective interdisciplinary therapy.

Keywords: Neuroendocrine tumor, squamous cell carcinoma, Adjuvant chemotherapy, Histopathology