IMPACT OF AGE ON ENDOMETRIAL BIOPSY OUTCOMES IN WOMEN: A CORRELATION WITH CLINICAL PRESENTATION AND HISTOPATHOLOGICAL FINDINGS

Abstract

Background: Endometrial biopsy is an essential test to evaluate endometrium or the inner lining of the uterus in various pathological conditions. Endometrial biopsy result is highly dependent on Age as endometrial pathophysiology, endometrial thickness and general risk profile differ with age.

Objective: To determine the association of age and clinical presentation on endometrial biopsy outcome.

Methods: A descriptive cross-sectional study will be done on 521 endometrial biopsy specimen reports at the histopathology section of the pathology department from 1st June 2022 to 15TH September 2024. Chi-square tests will be used to check the relationship of age groups in relation to histopathological results, and clinical presentation, by using SPSS version 25.

Results: Out of 521 women studied, in this study, we have divided them into four age groups. The highest level of malignancy was observed in women of 41-60 years, endometrial carcinoma 5(2.7%), endometrial hyperplasia (3.3%), and in >60 years highest number of endometrial carcinoma (44.4%). Most common clinical presentation among all age group was abnormal uterine bleeding. The histopathological results showed that, among the women in the 13-20 years age group, (34.4%) have dysfunctional endometrium, normal (21.9%), and no hyperplasia, while age group 21-40, normal endometrium (23.8%), endometrial carcinoma (0.3%), and endometrial hyperplasia (2.3%). However, the incidence of endometrial carcinoma in the ? 60 age group was (44.4%).

Conclusion: This study underlines the fact that age plays a significant role in clinical presentation of the disease, and mainly the histopathological findings in women who were subjected to endometrial biopsies.