COMPARISON BETWEEN EFFICACY OF CLARITHROMYCIN VERSUS CEFTRIAXONE IN THE TREATMENT OF COMMUNITY ACQUIRED PNEUMONIA IN CHILDREN

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Arshad khan
Muhammad Saleh Faisal
Iqbal Hussain
Waqar Hayat
Arif Jamal
Waheed Iqbal

Abstract

Objective: To compare the clinical effectiveness of clarithromycin and ceftriaxone in the treatment of community acquired pneumonia in pediatric patients.


Study design: Quasi experimental design


Materials and Methods: The study was carried out in the Pediatric department of Khyber Teaching Hospital, Peshawar. Duration of the study was 6 months for which a sample size of 140 patients was calculated by WHO software. Patients of both genders and age between 5 to 12 years, meeting the inclusion criteria were enrolled in the study. All the subjects were randomly divided in two groups (70 in each) where Group A was treated with ceftriaxone while Group B with clarithromycin. Efficacy of the study drugs were determined on the basis of clinical cure i.e. disease resolution after 48 hours of antibiotic therapy, afebrile state without taking antipyretics, respiratory rate <25/min and/or O2 saturation >96%.


Results: Efficacy in terms of improvement in fever, respiratory rate and O2 saturation was analyzed and clarithromycin was found to be effective in 90% subjects whereas ceftriaxone in 84% subjects.


Conclusion: Clarithromycin is relatively more effective than ceftriaxone in the treatment of community acquired pneumonia in children.

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